A common NOS1AP genetic polymorphism is associated with increased cardiovascular mortality in users of dihydropyridine calcium channel blockers

AIM: Recently, a polymorphism in the NOS1AP gene (rs10494366), a regulator of neuronal nitric oxide synthase (nNOS), was associated with QTc prolongation. Both nNOS and calcium channel blockers (CCBs) regulate intracellular calcium levels and have an important role in cardiovascular homeostasis. The...

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Bibliographic Details
Main Authors:	Becker, Matthijs L, Visser, Loes E, Newton-Cheh, Christopher, Hofman, Albert, Uitterlinden, André G, Witteman, Jacqueline C M, Stricker, Bruno H Ch
Format:	Artigo
Language:	Inglês
Published:	Blackwell Science Inc 2009
Subjects:	Pharmacogenetics
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC2668085/ https://ncbi.nlm.nih.gov/pubmed/19076153 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2008.03325.x
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A common NOS1AP genetic polymorphism is associated with increased cardiovascular mortality in users of dihydropyridine calcium channel blockers

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