Co-administration of proton pump inhibitors delays elimination of plasma methotrexate in high-dose methotrexate therapy

AIM: To assess whether or not co-administration of proton pump inhibitors (PPIs) is a risk factor for delayed elimination of plasma methotrexate (MTX) in high-dose MTX (HDMTX) therapy for malignant diseases. METHODS: To assess the effects of PPI co-administration on elimination of plasma MTX, we exa...

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Autores principales: Suzuki, Kunihiro, Doki, Kosuke, Homma, Masato, Tamaki, Hirofumi, Hori, Satoko, Ohtani, Hisakazu, Sawada, Yasufumi, Kohda, Yukinao
Formato: Artigo
Lenguaje:Inglês
Publicado: Blackwell Science Inc 2009
Materias:
Drug Interactions
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2668083/
https://ncbi.nlm.nih.gov/pubmed/19076159
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2008.03303.x
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