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Large changes in the CRAC segment of the gp41 of HIV does not destroy fusion activity if the segment interacts with cholesterol

The membrane-proximal external region (MPER) of the gp41 fusion protein of HIV is highly conserved among isolates of this virus and is considered a target for vaccine development. This region also appears to play a role in membrane fusion as well as localization of the virus to cholesterol-rich doma...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Vishwanathan, Sundaram A., Thomas, Annick, Brasseur, Robert, Epand, Raquel F., Hunter, Eric, Epand, Richard M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2008
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2667962/
https://ncbi.nlm.nih.gov/pubmed/18937430
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi8014828
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