Identification of Threonine 348 as a Residue Involved in Aminopeptidase A Substrate Specificity

Aminopeptidase A (APA; EC 3.4.11.7) is a membrane-bound zinc metalloprotease cleaving in the brain the N-terminal aspartyl residue of angiotensin II to generate angiotensin III, which exerts a tonic stimulatory effect on the central control of blood pressure in hypertensive animals. We docked the sp...

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Main Authors: Claperon, Cédric, Banegas-Font, Inmaculada, Iturrioz, Xavier, Rozenfeld, Raphael, Maigret, Bernard, Llorens-Cortes, Catherine
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Enzyme Catalysis and Regulation
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2667749/
https://ncbi.nlm.nih.gov/pubmed/19228697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M806783200
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