Filarial Lymphedema Is Characterized by Antigen-Specific Th1 and Th17 Proinflammatory Responses and a Lack of Regulatory T Cells

BACKGROUND: Lymphatic filariasis can be associated with development of serious pathology in the form of lymphedema, hydrocele, and elephantiasis in a subset of infected patients. METHODS AND FINDINGS: To elucidate the role of CD4(+) T cell subsets in the development of lymphatic pathology, we examin...

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Главные авторы: Babu, Subash, Bhat, Sajid Q., Pavan Kumar, N., Lipira, Angelo B., Kumar, Sanath, Karthik, C., Kumaraswami, V., Nutman, Thomas B.
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2009
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Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2666805/
https://ncbi.nlm.nih.gov/pubmed/19381284
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0000420
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