Role of Phosphorylation and Basic Residues in the Catalytic Domain of Cytosolic Phospholipase A(2)α in Regulating Interfacial Kinetics and Binding and Cellular Function

Group IVA cytosolic phospholipase A(2) (cPLA(2)α) is regulated by phosphorylation and calcium-induced translocation to membranes. Immortalized mouse lung fibroblasts lacking endogenous cPLA(2)α (IMLF(-/-)) were reconstituted with wild type and cPLA(2)α mutants to investigate how calcium, phosphoryla...

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Detalhes bibliográficos
Main Authors: Tucker, Dawn E., Ghosh, Moumita, Ghomashchi, Farideh, Loper, Robyn, Suram, Saritha, John, Bonnie St., Girotti, Milena, Bollinger, James G., Gelb, Michael H., Leslie, Christina C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Mechanisms of Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2666612/
https://ncbi.nlm.nih.gov/pubmed/19176526
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M807299200
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