Role of Phosphorylation and Basic Residues in the Catalytic Domain of Cytosolic Phospholipase A(2)α in Regulating Interfacial Kinetics and Binding and Cellular Function

Group IVA cytosolic phospholipase A(2) (cPLA(2)α) is regulated by phosphorylation and calcium-induced translocation to membranes. Immortalized mouse lung fibroblasts lacking endogenous cPLA(2)α (IMLF(-/-)) were reconstituted with wild type and cPLA(2)α mutants to investigate how calcium, phosphoryla...

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Autores principales: Tucker, Dawn E., Ghosh, Moumita, Ghomashchi, Farideh, Loper, Robyn, Suram, Saritha, John, Bonnie St., Girotti, Milena, Bollinger, James G., Gelb, Michael H., Leslie, Christina C.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2009
Materias:
Mechanisms of Signal Transduction
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2666612/
https://ncbi.nlm.nih.gov/pubmed/19176526
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M807299200
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