Signal transducer and activator of transcription 3 in the heart transduces not only a hypertrophic signal but a protective signal against doxorubicin-induced cardiomyopathy

The signal transducer and activator of transcription (STAT) 3, a transcriptional factor downstream of several cytokines, is activated by Janus kinase families and plays a pivotal role in cardiac hypertrophy through gp130. To determine the physiological significance of STAT3 in vivo, transgenic mice...

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Hlavní autoři: Kunisada, Keita, Negoro, Shinji, Tone, Eiroh, Funamoto, Masanobu, Osugi, Tomoaki, Yamada, Shuichi, Okabe, Masaru, Kishimoto, Tadamitsu, Yamauchi-Takihara, Keiko
Médium: Artigo
Jazyk:Inglês
Vydáno: The National Academy of Sciences 2000
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC26660/
https://ncbi.nlm.nih.gov/pubmed/10618415
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