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From a Natural Product Lead to the Identification of Potent and Selective Benzofuran-3-yl-(indol-3-yl)maleimides as Glycogen Synthase Kinase 3β Inhibitors that Suppress Proliferation and Survival of Pancreatic Cancer Cells

Recent studies have demonstrated that Glycogen Synthase Kinase 3β (GSK-3β) is overexpressed in human colon and pancreatic carcinomas contributing to cancer cell proliferation and survival. Here, we report the design, synthesis, and biological evaluation of benzofuran-3-yl-(indol-3-yl)maleimides, pot...

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書誌詳細
主要な著者: Gaisina, Irina N., Gallier, Franck, Ougolkov, Andrei V., Kim, Ki H., Kurome, Toru, Guo, Songpo, Holzle, Denise, Luchini, Doris N., Blond, Sylvie Y., Billadeau, Daniel D., Kozikowski, Alan P.
フォーマット: Artigo
言語:Inglês
出版事項: 2009
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2665923/
https://ncbi.nlm.nih.gov/pubmed/19338355
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm801317h
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