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A seizure-induced gain-of-function in BK channels is associated with elevated firing activity in neocortical pyramidal neurons
A heritable gain-of-function in BK channel activity has been associated with spontaneous seizures in both rodents and humans. We find that chemoconvulsant-induced seizures induce a gain-of-function in BK channel current that is associated with abnormal, elevated network excitability. Action potentia...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2665726/ https://ncbi.nlm.nih.gov/pubmed/18387812 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2008.02.002 |
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