Prophylactic DNA vaccine for hepatitis C virus (HCV) infection: HCV-specific cytotoxic T lymphocyte induction and protection from HCV-recombinant vaccinia infection in an HLA-A2.1 transgenic mouse model

DNA vaccines express antigens intracellularly and effectively induce cellular immune responses. Because only chimpanzees can be used to model human hepatitis C virus (HCV) infections, we developed a small-animal model using HLA-A2.1-transgenic mice to test induction of HLA-A2.1-restricted cytotoxic...

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הוצא לאור ב:	Proc Natl Acad Sci U S A
Principais autores:	Arichi, Tatsumi, Saito, Takafumi, Major, Marian E., Belyakov, Igor M., Shirai, Mutsunori, Engelhard, Victor H., Feinstone, Stephen M., Berzofsky, Jay A.
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	National Academy of Sciences 2000
נושאים:	Biological Sciences
גישה מקוונת:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC26657/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10618412/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.97.1.297
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