Effect of Simvastatin on Cognitive Functioning in Children With Neurofibromatosis Type 1: A Randomized Controlled Trial

CONTEXT: Neurofibromatosis type 1 (NF1) is among the most common genetic disorders that cause learning disabilities. Recently, it was shown that statin-mediated inhibition of 3-hydroxy-3-methylglutaryl coenzyme A reductase restores the cognitive deficits in an NF1 mouse model. OBJECTIVE: To determin...

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Hlavní autoři: Krab, Lianne C., de Goede-Bolder, Arja, Aarsen, Femke K., Pluijm, Saskia M. F., Bouman, Marlies J., van der Geest, Jos N., Lequin, Maarten, Catsman, Coriene E., Arts, Willem Frans M., Kushner, Steven A., Silva, Alcino J., de Zeeuw, Chris I., Moll, Henriëtte A., Elgersma, Ype
Médium: Artigo
Jazyk:Inglês
Vydáno: 2008
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2664742/
https://ncbi.nlm.nih.gov/pubmed/18632543
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jama.300.3.287
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