Induction of a Chronic Disease State in Patients With Smoldering or Indolent Multiple Myeloma by Targeting Interleukin 1β-Induced Interleukin 6 Production and the Myeloma Proliferative Component

OBJECTIVE: To conduct in vitro studies as well as a phase 2 clinical trial in patients with smoldering or indolent multiple myeloma to determine if interleukin 1 (IL-1) inhibitors can delay or prevent active myeloma. PATIENTS AND METHODS: Stromal cells were cocultured with IL-1β-expressing myeloma c...

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Main Authors: Lust, John A., Lacy, Martha Q., Zeldenrust, Steven R., Dispenzieri, Angela, Gertz, Morie A., Witzig, Thomas E., Kumar, Shaji, Hayman, Suzanne R., Russell, Stephen J., Buadi, Francis K., Geyer, Susan M., Campbell, Megan E., Kyle, Robert A., Rajkumar, S. Vincent, Greipp, Philip R., Kline, Michael P., Xiong, Yuning, Moon-Tasson, Laurie L., Donovan, Kathleen A.
Format: Artigo
Sprog:Inglês
Udgivet: Mayo Foundation for Medical Education and Research 2009
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Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2664581/
https://ncbi.nlm.nih.gov/pubmed/19181644
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