Cholesterol supplementation during production increases the infectivity of retroviral and lentiviral vectors pseudotyped with the vesicular stomatitis virus glycoprotein (VSV-G)

Cholesterol, a major component of plasma membrane lipid rafts, is important for assembly and budding of enveloped viruses, including influenza and HIV-1. Cholesterol depletion impairs virus assembly and infectivity. This study examined the effects of exogenous cholesterol addition (delivered as a co...

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Main Authors: Chen, Yong, Ott, Christopher J., Townsend, Kay, Subbaiah, Papasani, Aiyar, Ashok, Miller, William M.
Formato: Artigo
Idioma:Inglês
Publicado: Elsevier B.V. 2009
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2663912/
https://ncbi.nlm.nih.gov/pubmed/20160854
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bej.2008.12.004
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