A prime/boost DNA/Modified vaccinia virus Ankara vaccine expressing recombinant Leishmania DNA encoding TRYP is safe and immunogenic in outbred dogs, the reservoir of zoonotic visceral leishmaniasis

Previous studies demonstrated safety, immunogenicity and efficacy of DNA/modified vaccinia virus Ankara (MVA) prime/boost vaccines expressing tryparedoxin peroxidase (TRYP) and Leishmania homologue of the mammalian receptor for activated C kinase (LACK) against Leishmania major challenge in mice, wh...

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Detalhes bibliográficos
Main Authors: Carson, Connor, Antoniou, Maria, Ruiz-Argüello, Maria Begoña, Alcami, Antonio, Christodoulou, Vasiliki, Messaritakis, Ippokratis, Blackwell, Jenefer M., Courtenay, Orin
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier Science 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2663027/
https://ncbi.nlm.nih.gov/pubmed/19095029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vaccine.2008.11.094
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