Interaction of phosphodiesterase 3A with brefeldin A-inhibited guanine nucleotide-exchange proteins BIG1 and BIG2 and effect on ARF1 activity

ADP-ribosylation factors (ARFs) have crucial roles in vesicular trafficking. Brefeldin A-inhibited guanine nucleotide-exchange proteins (BIG)1 and BIG2 catalyze the activation of class I ARFs by accelerating replacement of bound GDP with GTP. Several additional and differing actions of BIG1 and BIG2...

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Detalhes bibliográficos
Main Authors: Puxeddu, Ermanno, Uhart, Marina, Li, Chun-Chun, Ahmad, Faiyaz, Pacheco-Rodriguez, Gustavo, Manganiello, Vincent C., Moss, Joel, Vaughan, Martha
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2009
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2662965/
https://ncbi.nlm.nih.gov/pubmed/19332778
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0901558106
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