Wnt inhibitory factor 1 is epigenetically silenced in human osteosarcoma, and targeted disruption accelerates osteosarcomagenesis in mice

Wnt signaling increases bone mass by stimulating osteoblast lineage commitment and expansion and forms the basis for novel anabolic therapeutic strategies being developed for osteoporosis. These strategies include derepression of Wnt signaling by targeting secreted Wnt pathway antagonists, such as s...

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Détails bibliographiques
Auteurs principaux: Kansara, Maya, Tsang, Michael, Kodjabachian, Laurent, Sims, Natalie A., Trivett, Melanie K., Ehrich, Mathias, Dobrovic, Alexander, Slavin, John, Choong, Peter F.M., Simmons, Paul J., Dawid, Igor B., Thomas, David M.
Format: Artigo
Langue:Inglês
Publié: American Society for Clinical Investigation 2009
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2662557/
https://ncbi.nlm.nih.gov/pubmed/19307728
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI37175
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