Membrane-anchored uPAR regulates the proliferation, marrow pool size, engraftment, and mobilization of mouse hematopoietic stem/progenitor cells

The mechanisms of BM hematopoietic stem/progenitor cell (HSPC) adhesion, engraftment, and mobilization remain incompletely identified. Here, using WT and transgenic mice, we have shown that membrane-anchored plasminogen activator, urokinase receptor ((M)uPAR) marks a subset of HSPCs and promotes the...

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Hlavní autoři: Tjwa, Marc, Sidenius, Nicolai, Moura, Rute, Jansen, Sandra, Theunissen, Koen, Andolfo, Annapaola, De Mol, Maria, Dewerchin, Mieke, Moons, Lieve, Blasi, Francesco, Verfaillie, Catherine, Carmeliet, Peter
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2009
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2662545/
https://ncbi.nlm.nih.gov/pubmed/19273908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI36010
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