Glomerular type 1 angiotensin receptors augment kidney injury and inflammation in murine autoimmune nephritis

Studies in humans and animal models indicate a key contribution of angiotensin II to the pathogenesis of glomerular diseases. To examine the role of type 1 angiotensin (AT(1)) receptors in glomerular inflammation associated with autoimmune disease, we generated MRL-Fas(lpr/lpr) (lpr) mice lacking th...

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Main Authors: Crowley, Steven D., Vasievich, Matthew P., Ruiz, Phillip, Gould, Samantha K., Parsons, Kelly K., Pazmino, A. Kathy, Facemire, Carie, Chen, Benny J., Kim, Hyung-Suk, Tran, Trinh T., Pisetsky, David S., Barisoni, Laura, Prieto-Carrasquero, Minolfa C., Jeansson, Marie, Foster, Mary H., Coffman, Thomas M.
格式: Artigo
語言:Inglês
出版: American Society for Clinical Investigation 2009
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2662542/
https://ncbi.nlm.nih.gov/pubmed/19287096
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI34862
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