Analyses of Group III Secreted Phospholipase A(2) Transgenic Mice Reveal Potential Participation of This Enzyme in Plasma Lipoprotein Modification, Macrophage Foam Cell Formation, and Atherosclerosis

Among the many mammalian secreted phospholipase A(2) (sPLA(2)) enzymes, PLA2G3 (group III secreted phospholipase A(2)) is unique in that it possesses unusual N- and C-terminal domains and in that its central sPLA(2) domain is homologous to bee venom PLA(2) rather than to other mammalian sPLA(2)s. To...

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Main Authors: Sato, Hiroyasu, Kato, Rina, Isogai, Yuki, Saka, Go-ichi, Ohtsuki, Mitsuhiro, Taketomi, Yoshitaka, Yamamoto, Kei, Tsutsumi, Kae, Yamada, Joe, Masuda, Seiko, Ishikawa, Yukio, Ishii, Toshiharu, Kobayashi, Tetsuyuki, Ikeda, Kazutaka, Taguchi, Ryo, Hatakeyama, Shinji, Hara, Shuntaro, Kudo, Ichiro, Itabe, Hiroyuki, Murakami, Makoto
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2008
Assuntos:
Lipids and Lipoproteins: Metabolism, Regulation, and Signaling
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2662271/
https://ncbi.nlm.nih.gov/pubmed/18801741
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M804628200
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