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Impaired Regulation of Brain Mitochondria by Extramitochondrial Ca(2+) in Transgenic Huntington Disease Rats
Huntington disease (HD) is characterized by polyglutamine expansions of huntingtin (htt), but the underlying pathomechanisms have remained unclear. We studied brain mitochondria of transgenic HD rats with 51 glutamine repeats (htt(51Q)), modeling the adult form of HD. [Formula: see text] up to 2 μm...
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| Main Authors: | , , , , , , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
American Society for Biochemistry and Molecular Biology
2008
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2662157/ https://ncbi.nlm.nih.gov/pubmed/18606820 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M709555200 |
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