Von Hippel-Lindau ^ Coupled and Transcription-Coupled Nucleotide Excision Repair ^ Dependent Degradation of RNA Polymerase II in Response to Trabectedin

PURPOSE: Ecteinascidin 743 (Et743; trabectedin, Yondelis) has recently been approved in Europe for the treatment of soft tissue sarcomas and is undergoing clinical trials for other solid tumors. Et743 selectively targets cells proficient for TC-NER, which sets it apart from other DNA alkylating agen...

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Bibliographic Details
Main Authors: Aune, Gregory J., Takagi, Kazutaka, Sordet, Olivier, Guirouilh-Barbat, Jose, Antony, Smitha, Bohr, Vilhelm A., Pommier, Yves
Format: Artigo
Language:Inglês
Published: 2008
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2662138/
https://ncbi.nlm.nih.gov/pubmed/18927284
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-08-0730
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