Isoquinoline-1,3,4-trione Derivatives Inactivate Caspase-3 by Generation of Reactive Oxygen Species

Caspase-3 is an attractive therapeutic target for treatment of diseases involving disregulated apoptosis. We report here the mechanism of caspase-3 inactivation by isoquinoline-1,3,4-trione derivatives. Kinetic analysis indicates the compounds can irreversibly inactivate caspase-3 in a 1,4-dithiothr...

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Autors principals: Du, Jun-Qing, Wu, Jian, Zhang, Hua-Jie, Zhang, Ya-Hui, Qiu, Bei-Ying, Wu, Fang, Chen, Yi-Hua, Li, Jing-Ya, Nan, Fa-Jun, Ding, Jian-Ping, Li, Jia
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2008
Matèries:
Enzyme Catalysis and Regulation
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2662080/
https://ncbi.nlm.nih.gov/pubmed/18768468
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M803347200
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