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Insights into the Catalytic Mechanism of Tyrosine Phenol-lyase from X-ray Structures of Quinonoid Intermediates

Amino acid transformations catalyzed by a number of pyridoxal 5′-phosphate (PLP)-dependent enzymes involve abstraction of the Cα proton from an external aldimine formed between a substrate and the cofactor leading to the formation of a quinonoid intermediate. Despite the key role played by the quino...

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書誌詳細
主要な著者: Milić, Dalibor, Demidkina, Tatyana V., Faleev, Nicolai G., Matković-Čalogović, Dubravka, Antson, Alfred A.
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Biochemistry and Molecular Biology 2008
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2662015/
https://ncbi.nlm.nih.gov/pubmed/18715865
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M802061200
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