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Insights into the Catalytic Mechanism of Tyrosine Phenol-lyase from X-ray Structures of Quinonoid Intermediates
Amino acid transformations catalyzed by a number of pyridoxal 5′-phosphate (PLP)-dependent enzymes involve abstraction of the Cα proton from an external aldimine formed between a substrate and the cofactor leading to the formation of a quinonoid intermediate. Despite the key role played by the quino...
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| 主要な著者: | , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Society for Biochemistry and Molecular Biology
2008
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| 主題: | |
| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2662015/ https://ncbi.nlm.nih.gov/pubmed/18715865 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M802061200 |
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