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N-Glycan-mediated Quality Control in the Endoplasmic Reticulum Is Required for the Expression of Correctly Folded δ-Opioid Receptors at the Cell Surface

A great majority of G protein-coupled receptors are modified by N-glycosylation, but the functional significance of this modification for receptor folding and intracellular transport has remained elusive. Here we studied these phenomena by mutating the two N-terminal N-glycosylation sites (Asn(18) a...

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Detalhes bibliográficos
Main Authors: Markkanen, Piia M. H., Petäjä-Repo, Ulla E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2662010/
https://ncbi.nlm.nih.gov/pubmed/18703511
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M801880200
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