Prolyl 4-hydroxylation regulates Argonaute 2 stability

Human Argonaute (Ago) proteins are essential components of the RNA-induced silencing complexes (RISCs). Argonaute 2 (Ago2) has a P-element-induced wimpy testis (PIWI) domain, which folds like RNase H and is responsible for target RNA cleavage in RNA interference1. Proteins such as Dicer, TRBP, MOV10...

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Bibliographic Details
Main Authors: Qi, Hank H., Ongusaha, Pat P., Myllyharju, Johanna, Cheng, Dongmei, Pakkanen, Outi, Shi, Yujiang, Lee, Sam W., Peng, Junmin, Shi, Yang
Format: Artigo
Language:Inglês
Published: 2008
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2661850/
https://ncbi.nlm.nih.gov/pubmed/18690212
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature07186
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