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Differential 3′ splice site recognition of SMN1 and SMN2 transcripts by U2AF and U2 snRNP
Spinal Muscular atrophy is a prevalent genetic disease caused by mutation of the SMN1 gene, which encodes the SMN protein involved in assembly of small nuclear ribonucleoprotein (snRNP) complexes. A paralog of the gene, SMN2, cannot provide adequate levels of functional SMN because exon 7 is skipped...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cold Spring Harbor Laboratory Press
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2661831/ https://ncbi.nlm.nih.gov/pubmed/19244360 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.1273209 |
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