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The Ratio of Monomeric to Aggregated Forms of Aβ40 and Aβ42 Is an Important Determinant of Amyloid-β Aggregation, Fibrillogenesis, and Toxicity
Aggregation and fibril formation of amyloid-β (Aβ) peptides Aβ40 and Aβ42 are central events in the pathogenesis of Alzheimer disease. Previous studies have established the ratio of Aβ40 to Aβ42 as an important factor in determining the fibrillogenesis, toxicity, and pathological distribution of Aβ....
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| Autori principali: | , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Biochemistry and Molecular Biology
2008
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2661389/ https://ncbi.nlm.nih.gov/pubmed/18694930 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M803159200 |
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