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A new theory of MHC evolution: beyond selection on the immune genes
The major histocompatibility complex (MHC) is a dense region of immune genes with high levels of polymorphism, which are arranged in haplotype blocks. Traditional models of balancing selection (i.e. overdominance and negative frequency dependence) were developed to study the population genetics of s...
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| Autor principal: | |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Royal Society
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2660941/ https://ncbi.nlm.nih.gov/pubmed/18986972 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rspb.2008.1299 |
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