Complexity of the Inoculum Determines the Rate of Reversion of SIV Gag CD8 T Cell Mutant Virus and Outcome of Infection

Escape mutant (EM) virus that evades CD8+ T cell recognition is frequently observed following infection with HIV-1 or SIV. This EM virus is often less replicatively “fit” compared to wild-type (WT) virus, as demonstrated by reversion to WT upon transmission of HIV to a naïve host and the association...

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Hauptverfasser: Loh, Liyen, Reece, Jeanette C., Fernandez, Caroline S., Alcantara, Sheilajen, Center, Robert, Howard, Jane, Purcell, Damian F. J., Balamurali, Mehala, Petravic, Janka, Davenport, Miles P., Kent, Stephen J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2009
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2660429/
https://ncbi.nlm.nih.gov/pubmed/19360124
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1000378
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