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Safety and efficacy of quinacrine in human prion disease (PRION-1 study): a patient-preference trial
BACKGROUND: The propagation of prions, the causative agents of Creutzfeldt-Jakob disease and other human prion diseases, requires post-translational conversion of normal cellular prion protein to disease-associated forms. The antimalarial drug quinacrine (mepacrine) prevents this conversion in vitro...
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| 主要な著者: | , , , , , , , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Lancet Pub. Group
2009
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2660392/ https://ncbi.nlm.nih.gov/pubmed/19278902 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/S1474-4422(09)70049-3 |
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