Neither fibrin nor plasminogen activator inhibitor-1 deficiency protects lung function in a mouse model of acute lung injury

Fibrin impairs surfactant function in vitro, and inhibition of fibrinolysis by plasminogen activator inhibitor (PAI-1) is thought to promote fibrin accumulation in acute lung injury (ALI). This has led to speculation that impaired PAI-1 and fibrin accumulation should protect lung function in ALI. We...

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Autori principali: Allen, Gilman B., Cloutier, Mary E., Larrabee, Yuna C., Tetenev, Konstantin, Smiley, Stephen T., Bates, Jason H. T.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Physiological Society 2009
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Editorial Focus
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2660214/
https://ncbi.nlm.nih.gov/pubmed/19060228
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.90475.2008
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