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A population-based study of the drug interaction between proton pump inhibitors and clopidogrel

BACKGROUND: Most proton pump inhibitors inhibit the bioactivation of clopidogrel to its active metabolite. The clinical significance of this drug interaction is unknown. METHODS: We conducted a population-based nested case–control study among patients aged 66 years or older who commenced clopidogrel...

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Autori principali: Juurlink, David N., Gomes, Tara, Ko, Dennis T., Szmitko, Paul E., Austin, Peter C., Tu, Jack V., Henry, David A., Kopp, Alex, Mamdani, Muhammad M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Canadian Medical Association 2009
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2659819/
https://ncbi.nlm.nih.gov/pubmed/19176635
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1503/cmaj.082001
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