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Inefficient Quality Control of Thermosensitive Proteins on the Plasma Membrane

BACKGROUND: Misfolded proteins are generally recognised by cellular quality control machinery, which typically results in their ubiquitination and degradation. For soluble cytoplasmic proteins, degradation is mediated by the proteasome. Membrane proteins that fail to fold correctly are subject to ER...

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Detalhes bibliográficos
Main Authors: Lewis, Michael J., Pelham, Hugh R. B.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2659772/
https://ncbi.nlm.nih.gov/pubmed/19337370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0005038
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