The Haptoglobin 2-2 Genotype Is Associated with a Reduced Incidence of Plasmodium falciparum Malaria in Children on the Coast of Kenya

BACKGROUND: Haptoglobin (Hp) genotype determines the efficiency of hemoglobin clearance after malaria-induced hemolysis and alters antioxidant and immune functions. The Hp(2) allele is thought to have spread under strong selection pressure, but it is unclear whether this is due to protection from ma...

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Main Authors: Atkinson, Sarah H., Mwangi, Tabitha W., Uyoga, Sophie M., Ogada, Edna, Macharia, Alex W., Marsh, Kevin, Prentice, Andrew M., Williams, Thomas N.
Format: Artigo
Jezik:Inglês
Izdano: 2007
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2659731/
https://ncbi.nlm.nih.gov/pubmed/17304451
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1086/511868
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