Historic, Demographic, and Genetic Evidence for Increased Population Frequencies of CCR5Δ32 Mutation in Croatian Island Isolates after Lethal 15th Century Epidemics

AIM: To assess the frequency of 32 base pair deletion in CCR5 (CCR5Δ32), which has been shown to confer resistance to HIV infection in a homozygous form, in 10 isolated island communities of Dalmatia, Croatia, with different histories of exposure to epidemics during and since the medieval period. ME...

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Detalhes bibliográficos
Main Authors: Biloglav, Zrinka, Zgaga, Lina, Smoljanović, Mladen, Hayward, Caroline, Polašek, Ozren, Kolčić, Ivana, Vitart, Veronique, Zemunik, Tatijana, Boraska, Vesna, Torlak, Vesela, Mulić, Rosanda, Ropac, Darko, Grković, Ivica, Rudan, Diana, Ristić, Smiljana, Barbalić, Maja, Campbell, Harry, Wright, Alan F., Rudan, Igor
Formato: Artigo
Idioma:Inglês
Publicado em: Croatian Medical Schools 2009
Assuntos:
Genomics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2657566/
https://ncbi.nlm.nih.gov/pubmed/19260142
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3325/cmj.2009.50.34
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