Impaired maturation of dendritic spines without disorganization of cortical cell layers in mice lacking NRG1/ErbB signaling in the central nervous system

Neuregulin-1 (NRG1) and its ErbB2/B4 receptors are encoded by candidate susceptibility genes for schizophrenia, yet the essential functions of NRG1 signaling in the CNS are still unclear. Using CRE/LOX technology, we have inactivated ErbB2/B4-mediated NRG1 signaling specifically in the CNS. In contr...

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Bibliografiska uppgifter
Huvudupphovsmän: Barros, Claudia S., Calabrese, Barbara, Chamero, Pablo, Roberts, Amanda J., Korzus, Ed, Lloyd, Kent, Stowers, Lisa, Mayford, Mark, Halpain, Shelley, Müller, Ulrich
Materialtyp: Artigo
Språk:Inglês
Publicerad: National Academy of Sciences 2009
Ämnen:
Biological Sciences
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2657442/
https://ncbi.nlm.nih.gov/pubmed/19240213
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0900355106
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