Deoxycholate promotes survival of breast cancer cells by reducing the level of pro-apoptotic ceramide

INTRODUCTION: At physiologic concentration in serum, the bile acid sodium deoxycholate (DC) induces survival and migration of breast cancer cells. Here we provide evidence of a novel mechanism by which DC reduces apoptosis that is induced by the sphingolipid ceramide in breast cancer cells. METHODS:...

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Main Authors: Krishnamurthy, Kannan, Wang, Guanghu, Rokhfeld, Dmitriy, Bieberich, Erhard
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2008
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2656903/
https://ncbi.nlm.nih.gov/pubmed/19087284
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/bcr2211
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