Inhibition of Hsp90 leads to cell cycle arrest and apoptosis in human malignant pleural mesothelioma

Heat shock protein 90 (Hsp90) is an abundant molecular chaperone that mediates the maturation and stability of a variety of proteins associated with the promotion of cell growth and survival. Inhibition of Hsp90 function leads to proteasomal degradation of its mis-folded client proteins. Recently, H...

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Detalhes bibliográficos
Main Authors: Okamoto, Junichi, Mikami, Iwao, Tominaga, Yuichi, Kuchenbecker, Kristopher M., Lin, Yu-Ching, Bravo, Dawn T., Clement, Genevieve, Yagui-Beltran, Adam, Ray, M. Roshni, Koizumi, Kiyoshi, He, Biao, Jablons, David M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2656438/
https://ncbi.nlm.nih.gov/pubmed/18827603
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/JTO.0b013e3181839693
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