Expression of sprouty2 inhibits B-cell proliferation and is epigenetically silenced in mouse and human B-cell lymphomas

B-cell lymphoma is the most common immune system malignancy. TCL1 transgenic mice (TCL1-tg), in which TCL1 is ectopically expressed in mature lymphocytes, develop multiple B- and T-cell leukemia and lymphoma subtypes, supporting an oncogenic role for TCL1 that probably involves AKT and MAPK-ERK sign...

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Détails bibliographiques
Auteurs principaux: Frank, Matthew J., Dawson, David W., Bensinger, Steven J., Hong, Jason S., Knosp, Wendy M., Xu, Lizhong, Balatoni, Cynthia E., Allen, Eric L., Shen, Rhine R., Bar-Sagi, Dafna, Martin, Gail R., Teitell, Michael A.
Format: Artigo
Langue:Inglês
Publié: American Society of Hematology 2009
Sujets:
Lymphoid Neoplasia
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2656273/
https://ncbi.nlm.nih.gov/pubmed/19147787
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-05-156943
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