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Furan-modified oligonucleotides for fast, high-yielding and site-selective DNA inter-strand cross-linking with non-modified complements(†)

Among the various types of DNA damage, inter-strand cross-links (ICL) represent one of the most cytotoxic lesions. Processes such as transcription and replication can be fully blocked by ICLs, as shown by the mechanism of action of some anticancer drugs. However, repair of ICLs can be a possible cau...

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Hlavní autoři: Stevens, Kristof, Madder, Annemieke
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2009
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2655669/
https://ncbi.nlm.nih.gov/pubmed/19151089
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkn1077
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