Vesicular Stomatitis Virus M Protein Mutant Stimulates Maturation of Toll-Like Receptor 7 (TLR7)-Positive Dendritic Cells through TLR-Dependent and -Independent Mechanisms

Wild-type (wt) vesicular stomatitis virus (VSV) strains stimulate plasmacytoid dendritic cells (pDC) through Toll-like receptor 7 (TLR7) and its adaptor molecule, MyD88. Granulocyte-macrophage colony-stimulating factor-derived DC (G-DC), which do not express TLR7, are unresponsive to wt VSV due to i...

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Bibliographic Details
Main Authors: Ahmed, Maryam, Mitchell, Latoya M., Puckett, Shelby, Brzoza-Lewis, Kristina L., Lyles, Douglas S., Hiltbold, Elizabeth M.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2009
Subjects:
Cellular Response to Infection
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2655538/
https://ncbi.nlm.nih.gov/pubmed/19144711
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02030-08
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