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Prediction of specificity-determining residues for small-molecule kinase inhibitors
BACKGROUND: Designing small-molecule kinase inhibitors with desirable selectivity profiles is a major challenge in drug discovery. A high-throughput screen for inhibitors of a given kinase will typically yield many compounds that inhibit more than one kinase. A series of chemical modifications are u...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
BioMed Central
2008
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| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2655090/ https://ncbi.nlm.nih.gov/pubmed/19032760 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2105-9-491 |
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