Down-regulation of the Notch Pathway in Human Airway Epithelium in Association with Smoking and Chronic Obstructive Pulmonary Disease

Rationale: The airway epithelium of smokers is subject to a variety of mechanisms of injury with consequent modulation of epithelial regeneration and disordered differentiation. Several signaling pathways, including the Notch pathway, control epithelial differentiation in lung morphogenesis, but lit...

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Detalhes bibliográficos
Main Authors: Tilley, Ann E., Harvey, Ben-Gary, Heguy, Adriana, Hackett, Neil R., Wang, Rui, O'Connor, Timothy P., Crystal, Ronald G.
Formato: Artigo
Idioma:Inglês
Publicado em: American Thoracic Society 2009
Assuntos:
B. Chronic Obstructive Pulmonary Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2654975/
https://ncbi.nlm.nih.gov/pubmed/19106307
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1164/rccm.200705-795OC
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