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Developmental Programming: Excess Weight Gain Amplifies the Effects of Prenatal Testosterone Excess On Reproductive Cyclicity—Implication for Polycystic Ovary Syndrome

Sheep exposed to testosterone (T) during early to midgestation exhibit reproductive defects that include hypergonadotropism, functional hyperandrogenism, polycystic ovaries, and anovulatory infertility, perturbations similar to those observed in women with polycystic ovary syndrome. Obesity increase...

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Detalhes bibliográficos
Main Authors: Steckler, Teresa L., Herkimer, Carol, Dumesic, Daniel A., Padmanabhan, Vasantha
Formato: Artigo
Idioma:Inglês
Publicado em: The Endocrine Society 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2654744/
https://ncbi.nlm.nih.gov/pubmed/18974266
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2008-1256
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