Better estimation of protein-DNA interaction parameters improve prediction of functional sites

BACKGROUND: Characterizing transcription factor binding motifs is a common bioinformatics task. For transcription factors with variable binding sites, we need to get many suboptimal binding sites in our training dataset to get accurate estimates of free energy penalties for deviating from the consen...

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Main Authors: Nagaraj, Vijayalakshmi H, O'Flanagan, Ruadhan A, Sengupta, Anirvan M
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2008
Assuntos:
Methodology Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2654563/
https://ncbi.nlm.nih.gov/pubmed/19105805
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1472-6750-8-94
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