Connective Tissue Growth Factor (CTGF) Inactivation Leads to Defects in Islet Cell Lineage Allocation and β-Cell Proliferation during Embryogenesis

The factors necessary for normal pancreatic islet morphogenesis have not been well characterized. Here we report that connective tissue growth factor (CTGF) is involved in the establishment of normal islet endocrine cell ratio and architecture. CTGF is a secreted protein known to modulate several gr...

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Auteurs principaux: Crawford, Laura A., Guney, Michelle A., Oh, Young Ah, DeYoung, R. Andrea, Valenzuela, David M., Murphy, Andrew J., Yancopoulos, George D., Lyons, Karen M., Brigstock, David R., Economides, Aris, Gannon, Maureen
Format: Artigo
Langue:Inglês
Publié: The Endocrine Society 2009
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2654514/
https://ncbi.nlm.nih.gov/pubmed/19131512
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2008-0045
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