Foxp3-dependent microRNA155 confers competitive fitness to regulatory T cells through targeting SOCS1

Foxp3(+) regulatory T (T(R)) cells limit pathogenic immune responses to self and foreign antigens. An essential role for microRNA (miRNA) in the maintenance and function of T(R) cells, revealed by the T(R)-specific Dicer ablation, raised a question as to a specific miRNA contribution. We found that...

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Main Authors: Lu, Li-Fan, Thai, To-Ha, Calado, Dinis Pedro, Chaudhry, Ashutosh, Kubo, Masato, Tanaka, Kentaro, Loeb, Gabriel B., Lee, Hana, Yoshimura, Akihiko, Rajewsky, Klaus, Rudensky, Alexander Y.
Formato: Artigo
Idioma:Inglês
Publicado: 2009
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2654249/
https://ncbi.nlm.nih.gov/pubmed/19144316
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2008.11.010
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