Transcriptome Analysis of Synaptoneurosomes Identifies Neuroplasticity Genes Overexpressed in Incipient Alzheimer's Disease

In Alzheimer's disease (AD), early deficits in learning and memory are a consequence of synaptic modification induced by toxic beta-amyloid oligomers (oAβ). To identify immediate molecular targets downstream of oAβ binding, we prepared synaptoneurosomes from prefrontal cortex of control and inc...

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Detalhes bibliográficos
Main Authors: Williams, Celia, Mehrian Shai, Ruty, Wu, Yongchun, Hsu, Ya-Hsuan, Sitzer, Traci, Spann, Bryan, McCleary, Carol, Mo, Yi, Miller, Carol A.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2009
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2654156/
https://ncbi.nlm.nih.gov/pubmed/19295912
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0004936
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