Three New Structures of Left-Handed RadA Helical Filaments: Structural Flexibility of N-Terminal Domain Is Critical for Recombinase Activity

RecA family proteins, including bacterial RecA, archaeal RadA, and eukaryotic Dmc1 and Rad51, mediate homologous recombination, a reaction essential for maintaining genome integrity. In the presence of ATP, these proteins bind a single-strand DNA to form a right-handed nucleoprotein filament, which...

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Main Authors: Chang, Yu-Wei, Ko, Tzu-Ping, Lee, Chien-Der, Chang, Yuan-Chih, Lin, Kuei-Ann, Chang, Chia-Seng, Wang, Andrew H.-J., Wang, Ting-Fang
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2009
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2654063/
https://ncbi.nlm.nih.gov/pubmed/19295907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0004890
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