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Ketohexokinase-Dependent Metabolism of Fructose Induces Proinflammatory Mediators in Proximal Tubular Cells

Increased consumption of fructose may play an important role in the epidemic of metabolic syndrome and may presage the development of diabetes, cardiovascular disease, and chronic kidney disease. Once in the cell, fructose is phosphorylated by ketohexokinase (KHK), leading to consumption of ATP, for...

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Detalhes bibliográficos
Main Authors: Cirillo, Pietro, Gersch, Michael S., Mu, Wei, Scherer, Philip M., Kim, Kyung Mee, Gesualdo, Loreto, Henderson, George N., Johnson, Richard J., Sautin, Yuri Y.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Nephrology 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2653686/
https://ncbi.nlm.nih.gov/pubmed/19158351
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2008060576
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